Abstract
Kaposi’s Sarcoma (KS) is a generalized angio-sarcoma caused by the Human Herpes Virus type 8 (HHV-8).
Infection by the Human Immunodeficiency Virus (HIV) has been shown to predispose to the development of
KS. The commonest location of KS lesions include the skin of the lower limbs, hard palate and gastrointestinal
system, lymph nodes and lungs. The occurrence of KS on the eye is considered rare. We report a case of a 45 year
old HIV positive female patient who presented with bilateral eyelid KS as the first manifestation of systemic KS.
Excisional biopsies were done on both eyelids. The histology showed fascicles of spindle cells and extravasation
of red blood cells. A histological diagnosis of bilateral eyelid KS was made.
References
Millet A, Singh S, Gittens-Backus G, Dang KA,
Shokrani B. An unusual case of invasive Kaposi’s
sarcoma with primary effusion lymphoma in an
HIV positive patient: case report and literature
review. Case Rep Oncol Med. 2015; 2015:
Teixeira AI, Neno M, Badura R, Borges-Costa
J, Filipe PL. Kaposi sarcoma of the eyelid as an
initial manifestation of AIDS. Dermatol Online J.
; 22(7): 3030/qt2jw6t7cs.
Restrepo CS, Martinez S, Lemos JA, Carrillo JA,
Lemos DF, Ojeda P, et al. Imaging manifestations
of Kaposi sarcoma. Radiographics. 2006; 26(4):
-85.
Pantanowitz L, Dezube BJ. Kaposi’s sarcoma in
unusual locations. BMC Cancer. 2008; 8: 190.
Mangombe S. Eyelid Kaposi’s sarcoma. SA J
Ophthalmol. 2017; 12(3): 13-15.
Schneider JW, Dittmer DP. Diagnosis and
treatment of Kaposi sarcoma. Am J Clin
Dermatol. 2017; 18(4): 529-539.
Crum-Cianflone NF, Hullsiek KH, Ganesan A,
Weintrob A, Okulicz JF, Agan BK. Is Kaposi’s
sarcoma occurring at higher CD4 cell counts over
the course of the HIV epidemic? AIDS. 2010;
(18): 2881-83.
Curtiss P, Strazzulla LC, Friedman-Kien AE.
An update on Kaposi’s sarcoma: Epidemiology,
pathogenesis and treatment. Dermatol Ther
(Heidelb). 2016; 6(4): 465-470.
Jacqueline Freudenthal et al. Ophthalmologic
manifestations of Kaposi’s sarcoma treatment and
management, https://emedicine.medscape.com/
article/1197815-treatment#d8, Medscape, 2019.
Dugel PU, Gill PS, Frangieh GT, Rao NA.
Treatment of ocular adnexal Kaposi’s sarcoma
in acquired immune deficiency syndrome.
Ophthalmology. 1992; 99(7):1127-32.
Kalinske M, Leone CR Jr. Kaposi’s sarcoma
involving eyelid and conjunctiva. Ann
Ophthalmol. 1982; 14:497–499.
Dammacco, R., L. Lapenna, et al. Solitary eyelid
Kaposi sarcoma in an HIV-negative patient.
Cornea. 2006; 25(4): 490-492.